PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4095)
Related Products (4095)
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PROTAC Linkers Isoform Comparison
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1,4-Bis(2-chloroethyl)piperazine
0 ImagesCat. No.: HY-W105692CAS No.: 1009-85-4
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Ethyl 2-(3-hydroxycyclobutyl)acetate
0 ImagesCat. No.: HY-W057683CAS No.: 1408075-22-8
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2-(4-(3-Bromopropoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
0 ImagesCat. No.: HY-W101211CAS No.: 957061-13-1
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Cbz-NH-PEG-alkyne
0 ImagesCat. No.: HY-W946552CAS No.: 2680859-66-7
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4-(4-Piperidyl)-1-butanol hydrochloride
0 ImagesCat. No.: HY-20845CAS No.: 199475-41-7Synonyms: 4-Piperidinebutanol hydrochloride
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Tridec-12-yn-1-ol
0 ImagesCat. No.: HY-W663742CAS No.: 18202-11-4
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tert-Butyl ((3-(aminomethyl)bicyclo[1.1.1]pentan-1-yl)methyl)carbamate
![tert-Butyl ((3-(aminomethyl)bicyclo[1.1.1]pentan-1-yl)methyl)carbamate](https://file.medchemexpress.com/product_pic/hy-w074255.gif "Click to View tert-Butyl ((3-(aminomethyl)bicyclo[1.1.1]pentan-1-yl)methyl)carbamate Product Detail")
0 ImagesCat. No.: HY-W074255CAS No.: 1638768-06-5
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Benzyl (4-bromobutyl)carbamate
0 ImagesCat. No.: HY-200226CAS No.: 101625-10-9
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Fmoc-11-aminoundecanoic acid
0 ImagesCat. No.: HY-W097110CAS No.: 88574-07-6Fmoc-11-aminoundecanoic acid can be used as a PROTAC linker in the synthesis of PROTACs and other conjugation applications. Fmoc-11-aminoundecanoic acid is an alkane chain with terminal Fmoc-protected amine and carboxylic acid groups. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
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FMOC-PEG7-CH2COOH
0 ImagesCat. No.: HY-W190794CAS No.: 152074-20-9
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2-(4-(Aminomethyl)piperidin-1-yl)acetonitrile dihydrochloride
0 ImagesCat. No.: HY-W377108CAS No.: 1354953-43-7
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tert-Butyl [3,3'-biazetidine]-1-carboxylate hydrochloride
![tert-Butyl [3,3'-biazetidine]-1-carboxylate hydrochloride](https://file.medchemexpress.com/product_pic/hy-w056646.gif "Click to View tert-Butyl [3,3'-biazetidine]-1-carboxylate hydrochloride Product Detail")
0 ImagesCat. No.: HY-W056646CAS No.: 2007910-70-3
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tert-Butyl 4-(piperidin-3-ylmethyl)piperazine-1-carboxylate
0 ImagesCat. No.: HY-W087218CAS No.: 1211569-09-3
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Propargyl-PEG2-methylamine
0 ImagesCat. No.: HY-140044CAS No.: 1835759-76-6Synonyms: Propargyl-PEG2-NHMePropargyl-PEG2-methylamine (Propargyl-PEG2-NHMe) is a PEG derivative containing a propargyl group and methylamine group. Propargyl-PEG2-methylamine is an PROTAC linker used in the synthesis of PROTACs. Propargyl-PEG2-methylamine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
